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Indicators of overdose incorporate hypotension and tachycardia or bradycardia. Terlipressin may very well be given to treat hypotension and tachycardia if conventional vasopressors fail to regulate blood pressure level.

Individuals experiencing an overdose might present with hypokalemia, hypochloremia, and hyponatremia. Treat patients with symptomatic and supportive treatment including fluids and electrolytes. Vasopressors may be administered to treat hypotension and oxygen may very well be provided for respiratory impairment.

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Irbesartan is a specific aggressive antagonist of AT1 receptors having a A great deal greater affinity (a lot more than 8500-fold) with the AT1 receptor than for the AT2 receptor, and no agonist action.

Blockade in the AT1 receptor eliminates the damaging suggestions of angiotensin II on renin secretion, though the ensuing improved plasma renin exercise and circulating angiotensin II tend not to conquer the effects of irbesartan on blood pressure.

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